Extracellular vesicles for the delivery of gene therapy
Gene therapy has brought hope for the treatment of previously incurable diseases, such as genetic disorders, cancers and autoimmune diseases. Howev…
Tag: Genetic vectors
Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids
The value of lipid nanoparticles (LNPs) for delivery of messenger RNA (mRNA) was demonstrated by the coronavirus disease 2019 (COVID-19) mRNA vacci…
Intracisternal vs intraventricular injection of AAV1 result in comparable, widespread transduction of the dog brain
Widespread distribution of transduced brain cells following delivery of AAV vectors into the cerebrospinal fluid (CSF) of the cisterna magna (CM) h…
AAV library screening identifies novel vector for efficient transduction of human aorta
Targeted gene delivery to vascular smooth muscle cells (VSMCs) could prevent or improve a variety of diseases affecting the vasculature and particu…