Effective CRISPR modulation of complex non-coding RNA loci
Tag: Genetics
Chromosomal inversion at the DG1 promoter drives double-grain spikelets and enhances grain yield in sorghum
The phenomenon of multiple-grain spikelets is frequently observed in gramineous crops. In the case of dual-floret spikelets, the upper fertile flor…
No evidence of positive causal effects of maternal and paternal age at first birth on children’s test scores at age 10 years
Research has shown that higher maternal and paternal age is positively associated with children’s education. Debate continues as to whether these…
Super pangenome of Vitis empowers identification of downy mildew resistance genes for grapevine improvement
Grapevine (Vitis) is one of the oldest domesticated fruit crops with great cultural and economic importance. Here we assembled and annotated…
Mitochondrial genetics, signalling and stress responses
Mitochondria are multifaceted organelles with crucial roles in energy generation, cellular signalling and a range of synthesis pathways. The study …
Human mood disorder risk gene Synaptotagmin-14 contributes to mania-like behaviors in mice
Bipolar disorder (BD) and major depressive disorder (MDD) are the most prevalent mood disorders and cause considerable burden worldwide. Compelling…
Using twin-pairs to assess potential bias in polygenic prediction of externalising behaviours across development
Prediction from polygenic scores may be confounded by sources of passive gene-environment correlation (rGE; e.g. population stratification, assorta…
Genome-wide analysis identifies novel shared loci between depression and white matter microstructure
Depression, a complex and heritable psychiatric disorder, is associated with alterations in white matter microstructure, yet their shared genetic b…