Family-based genome-wide association study designs for increased power and robustness
Family-based genome-wide association studies (FGWASs) use random, within-family genetic variation to remove confounding from estimates of direct ge…
Tag: Genome-wide association studies
An enhanced framework for local genetic correlation analysis
Genetic correlation is a key parameter in the joint genetic model of complex traits, but it is usually estimated on a global genomic scale. Underst…
A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies
Large-scale whole-genome sequencing (WGS) studies have improved our understanding of the contributions of coding and noncoding rare variants to com…
Association between genetically predicted leisure and social activities and cardiovascular disease and other health outcomes
Participation in leisure and social activities (LSA) is associated with better health outcomes and lower mortality1,2,3. Previous observ…
Contribution of rare variants to heritability of a disease is much greater than conventionally estimated: modification of allele distribution model
“Missing heritability” is a current problem in human genetics. I previously reported a method to estimate heritability of a polymorphism (h
Healthy lifestyle practice correlates with decreased obesity prevalence in individuals with high polygenic risk: TMM CommCohort study
Obesity and overweight, fundamental components of the metabolic syndrome, predispose individuals to lifestyle-related diseases. The extent to which…
Investigating mobile element variations by statistical genetics
The integration of structural variations (SVs) in statistical genetics provides an opportunity to understand the genetic factors influencing comple…
Multi-population GWAS detects robust marker associations in a newly established six-rowed winter barley breeding program
Genome-wide association study (GWAS) is a powerful tool for identifying marker-trait associations that can accelerate breeding progress. Yet, its p…