An in vivo platform to screen for regulators of Huntington’s disease
Tag: Genomic instability
Human polymerase θ helicase positions DNA microhomologies for double-strand break repair
DNA double-strand breaks occur daily in all human cells and must be repaired with high fidelity to minimize genomic instability. Deficiencies in hi…
The effects of loss of Y chromosome on male health
Loss of Y chromosome (LOY) is the most commonly occurring post-zygotic (somatic) mutation in male individuals. The past decade of research suggests…