Catalytic difluorocarbene insertion enables access to fluorinated oxetane isosteres
Skeletal editing of heterocyclic building blocks offers an appealing way to expand the accessible chemical space by diversifying molecular scaffold…
Tag: Homogeneous catalysis
Aryl halide cross-coupling via formate-mediated transfer hydrogenation
Transfer hydrogenation is widely practised across all segments of chemical industry, yet its application to aryl halide reductive cross-coupling is…
Site- and enantioselective allylic and propargylic C–H oxidation enabled by copper-based biomimetic catalysis
Methods for direct enantioselective oxidation of C(sp3)–H bonds will revolutionize the preparation of chiral alcohols and their…
A hydrogenative oxidation strategy for the single-step synthesis of lactams from N-heteroarenes using water
Using water as a hydrogen or oxygen source in organic synthesis has enabled various reductive and oxidative transformations, but incorporation of b…
Identifying a highly efficient molecular photocatalytic CO2 reduction system via descriptor-based high-throughput screening
Molecular metal complexes offer opportunities for developing artificial photocatalytic systems. The search for efficient molecular photocatalytic s…
Iron-catalysed alkenylzincation of allenes via electrophilicity reversal
Given the structural characteristics of allenes, nucleophilic additions usually occur at the electron-deficient central carbon atom of allene. Here…
C(sp3)–heteroatom bond formation by iron-catalyzed soft couplings
Carbon–heteroatom bonds are of great importance due to their prevalence in pharmaceuticals, agrochemicals, materials, and natural products. Despi…