Tag: Immunogenetics
Exploring changes in social spider DNA methylation profiles in all cytosine contexts following infection
Living at high density and with low genetic diversity are factors that should both increase the susceptibility of organisms to disease. Therefore, …
The HLA-B –21 M/T dimorphism associates with disease severity in COVID-19
Host genetics shape immune responses and influence severity of infectious diseases. The HLA-B –21 M/T dimorphism tunes the functionality…
Myeloid derived suppressor cells mediate hepatocyte proliferation and immune suppression during liver regeneration following resection
Liver regeneration following resection is a complex process relying on coordinated pathways and cell types in the remnant organ. Myeloid-Derived Su…
Regulatory T cells-related gene in primary sclerosing cholangitis: evidence from Mendelian randomization and transcriptome data
The present study utilized large-scale genome-wide association studies (GWAS) summary data (731 immune cell subtypes and three primary sclerosing c…
Systematic mining and quantification reveal the dominant contribution of non-HLA variations to acute graft-versus-host disease
Human leukocyte antigen (HLA) disparity between donors and recipients is a key determinant triggering intense alloreactivity, leading to a lethal c…