Engineering mycobacteria for vaccination and controlled human infection studies
Tag: Infectious diseases
Microbiota-derived succinate promotes enterohaemorrhagic Escherichia coli virulence via lysine succinylation
Succinate upregulates enterohaemorrhagic Escherichia coli (EHEC) virulence. Lysine succinylation, a post-translational modification, regulat…
PROTAR Vaccine 2.0 generates influenza vaccines by degrading multiple viral proteins
Manipulating viral protein stability using the cellular ubiquitin-proteasome system (UPS) represents a promising approach for developing live-atten…
Identification of nanaomycin A and its analogs by a newly established screening method for functional inhibitors of the type IX secretion system in Porphyromonas gingivalis
Porphyromonas gingivalis, a Gram-negative anaerobic bacterium, is a key pathogen in chronic periodontitis. P. gingivalis has a type I…
Bridging gene therapy and next-generation vaccine technologies
Contributions of the COVID-19 pandemic to gene-based vaccination Dealing with the serious problems of COVID-19 has propelled vaccine research and the importance of pandemic preparedness…
Association of breastfeeding practices during the first 12 months and subsequent infant respiratory tract infections: a prospective cohort study
Breastfeeding and human milk are the normative standards for infant feeding and nutrition.
IL-1Ī² drives SARS-CoV-2-induced disease independently of the inflammasome and pyroptosis signalling
Excessive inflammation and cytokine release are hallmarks of severe COVID-19. Certain programmed cell death processes can drive inflammation, howev…