Haematometabolism rewiring in atherosclerotic cardiovascular disease
Atherosclerotic cardiovascular diseases are the most frequent cause of death worldwide. The clinical complications of atherosclerosis are closely l…
Tag: Innate immunity
Targeting the mosquito prefoldin–chaperonin complex blocks Plasmodium transmission
The Plasmodium infection cycle in mosquitoes relies on numerous host factors in the vector midgut, which can be targeted with therapeutics. …
ADSL-generated fumarate binds and inhibits STING to promote tumour immune evasion
Highly aggressive tumours have evolved to restrain the cGAS–STING pathway for immune evasion, and the mechanisms underlying this hijacking remain…
Linking macrophage metabolism to function in the tumor microenvironment
Macrophages are present at high frequency in most solid tumor types, and their relative abundance negatively correlates with therapy responses and …
Interactions between gut microbes and host cells control gut barrier and metabolism
Gut microbes are now considered as key partners involved in human physiology. Data have shown that microbes contribute to regulate energy, lipid, a…
The need for Cre-loci controls in conditional mouse experiments: Mrp8-cre transgene predisposes mice to antibody-induced arthritis
The Cre/loxP system is extensively utilized to pinpoint gene functions in specific cell types or developmental stages, typically without major dist…
STAT1 mediates the pro-inflammatory role of GBP5 in colitis
Previous studies establish guanylate binding protein 5 (GBP5) as a driver in the development of inflammatory bowel diseases (IBDs). Here, we aim to…
Demyelination-derived lysophosphatidylserine promotes microglial dysfunction and neuropathology in a mouse model of Alzheimer’s disease
Microglia dysfunction-associated neuroinflammation is an important driver of Alzheimer’s disease (AD), but the mechanism is poorly understood. He…
The AhR-Ovol1-Id1 regulatory axis in keratinocytes promotes epidermal and immune homeostasis in atopic dermatitis-like skin inflammation
The skin is our outer permeability and immune defense barrier against myriad external assaults. Aryl hydrocarbon receptor (AhR) senses environmenta…