Plasma membrane-associated ARAF condensates fuel RAS-related cancer drug resistance
RAF protein kinases are major RAS effectors that function by phosphorylating MEK. Although all three RAF isoforms share a conserved RAS binding dom…
Tag: Kinases
Proteome selectivity profiling of photoaffinity probes derived from imidazopyrazine-kinase inhibitors
Kinases are attractive drug targets, but the design of highly selective kinase inhibitors remains challenging. Selectivity may be evaluated against…
Protein kinase A regulates ferroptosis by controlling GPX4 m6A modification through phosphorylation of ALKBH5
GPX4-dependent ferroptosis has emerged as a therapeutic strategy for cancer treatment. Here, we demonstrated that protein kinase A (PKA) participat…