Biomolecular condensates in immune cell fate
Fate decisions during immune cell development require temporally precise changes in gene expression. Evidence suggests that the dynamic modulation …
Tag: Lymphocytes
Paracrine FGF21 dynamically modulates mTOR signaling to regulate thymus function across the lifespan
Consequences of age-associated thymic atrophy include declining T-cell responsiveness to pathogens and vaccines and diminished T-cell self-toleranc…
Enhanced paracrine action of FGF21 in stromal cells delays thymic aging
Age-related thymic involution precedes aging of all other organs in vertebrates and initiates the process of declining T cell diversity, which lead…
Metabolic rewiring controlled by HIF-1α tunes IgA-producing B-cell differentiation and intestinal inflammation
Germinal centers where B cells undergo clonal expansion and antibody affinity maturation are hypoxic microenvironments. However, the function of hy…