Measuring plasma membrane fluidity using confocal microscopy
Membrane fluidity is a crucial parameter for cellular physiology. Recent evidence suggests that fluidity varies between cell types and states and i…
Tag: Membranes
Plasma membrane-associated ARAF condensates fuel RAS-related cancer drug resistance
RAF protein kinases are major RAS effectors that function by phosphorylating MEK. Although all three RAF isoforms share a conserved RAS binding dom…
Vastly different energy landscapes of the membrane insertions of monomeric gasdermin D and A3
Gasdermin D and gasdermin A3 belong to the same family of pore-forming proteins and executors of pyroptosis, a form of programmed cell death. To un…
Chemical linkers switch triglycerol detergents from bacterial protein purification to mild antibiotic amplification
Non-ionic detergents enable the investigation of cell membranes, including biomolecule purification and drug delivery. The question of whether non-…