Unlocking drug modes of action with multi-dimensional high-throughput metabolic profiling
Tag: Metabolomics
Quantifying metabolites using structure-switching aptamers coupled to DNA sequencing
Here we report a method, smol-seq (small-molecule sequencing), using structure-switching aptamers (SSAs) and DNA sequencing to quantify metabolites…
Amino acid auxotrophies in human gut bacteria are linked to higher microbiome diversity and long-term stability
Amino acid auxotrophies are prevalent among bacteria. They can govern ecological dynamics in microbial communities and indicate metabolic cross-fee…
Longitudinal assessment of maternal micronutrients (folate and vitamin B12) and homocysteine levels in women who develop gestational diabetes mellitus
Micronutrients (folate and vitamin B12) and homocysteine are key components of the one-carbon metabolism and literature on the associati…
Metabolite-driven mechanisms reveal chemical ecology of Lehmann Lovegrass (Eragrostis lehmanniana) invasion in North American semi-arid ecosystems
Invasive plants threaten global ecosystems, yet traditional analyses of functional traits cannot fully explain their dominance over co-occurring na…
Neurotensin-neurotensin receptor 2 signaling in adipocytes suppresses food intake through regulating ceramide metabolism
Neurotensin (NTS) is a secretory peptide produced by lymphatic endothelial cells. Our previous study revealed that NTS suppressed the activity of b…
Bone loss with aging is independent of gut microbiome in mice
Emerging evidence suggests a significant role of gut microbiome in bone health. Aging is well recognized as a crucial factor influencing the gut mi…