Systemic capillary leak syndrome
The vascular endothelial barrier maintains intravascular volume and metabolic homeostasis. Although plasma fluids and proteins extravasate continuo…
Tag: Molecular medicine
Peptide-enabled ribonucleoprotein delivery for CRISPR engineering (PERC) in primary human immune cells and hematopoietic stem cells
Peptide-enabled ribonucleoprotein delivery for CRISPR engineering (PERC) is a new approach for ex vivo genome editing of primary human cells. PERC …
mRNA lipid nanoparticle formulation, characterization and evaluation
mRNA-based therapies have emerged as a cutting-edge approach for diverse therapeutic applications. However, substantial barriers exist that hinder …
Association between genetically predicted leisure and social activities and cardiovascular disease and other health outcomes
Participation in leisure and social activities (LSA) is associated with better health outcomes and lower mortality1,2,3. Previous observ…
Small circular RNAs as vaccines for cancer immunotherapy
Messenger RNA vaccines have shown strong prophylactic efficacy against viral infections. Here we show that antigen-encoding small circular RNAs (ci…
A gut-on-a-chip incorporating human faecal samples and peristalsis predicts responses to immune checkpoint inhibitors for melanoma
Patient responses to immune checkpoint inhibitors can be influenced by the gastrointestinal microbiome. Mouse models can be used to study microbiom…
Timing of standard chow exposure determines the variability of mouse phenotypic outcomes and gut microbiota profile
Standard chow diets influence reproducibility in animal model experiments because chows have different nutrient compositions, which can independent…