Local structural flexibility drives oligomorphism in computationally designed protein assemblies
Many naturally occurring protein assemblies have dynamic structures that allow them to perform specialized functions. Although computational method…
Many naturally occurring protein assemblies have dynamic structures that allow them to perform specialized functions. Although computational method…
Gasdermin D and gasdermin A3 belong to the same family of pore-forming proteins and executors of pyroptosis, a form of programmed cell death. To un…
Naturally evolved T-cell receptors (TCRs) exhibit remarkably high specificity in discriminating non-self antigens from self-antigens under dynamic …
Supplementary information The Supplementary Information includes the detailed methods and workflow depositing the crystal structures, the procedure of model construction and simulations in molecular modeling…