Massively parallel in vivo Perturb-seq screening
Advances in genomics have identified thousands of risk genes impacting human health and diseases, but the functions of these genes and their mechan…
Tag: Molecular neuroscience
Astrocyte heterogeneity reveals region-specific astrogenesis in the white matter
Astrocyte heterogeneity has been well explored, but our understanding of white matter (WM) astrocytes and their distinctions from gray matter (GM) …
Neuronal polyunsaturated fatty acids are protective in ALS/FTD
Here we report a conserved transcriptomic signature of reduced fatty acid and lipid metabolism gene expression in a Drosophila model of C…
Genetically encoded biosensor for fluorescence lifetime imaging of PTEN dynamics in the intact brain
The phosphatase and tensin homolog (PTEN) is a vital protein that maintains an inhibitory brake for cellular proliferation and growth. Accordingly,…
Functional brain network dynamics mediate the relationship between female reproductive aging and interpersonal adversity
Premature reproductive aging is linked to heightened stress sensitivity and psychological maladjustment across the life course. However, the brain …
Enhanced mGluR5 availability marks the antidepressant efficacy in major depressive disorder: an [18F]FPEB PET study
The limited efficacy of antidepressants for major depressive disorder (MDD) underscores the urgent need to explore mechanisms behind treatment hete…
Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer’s disease
Alzheimer’s disease (AD) therapies utilizing amyloid-β (Aβ) immunization have shown potential in clinical trials. Yet, the mechanisms driving A…
Quantitative chemoproteomics reveals dopamine’s protective modification of Tau
Dopamine (DA) is one of the most important neurotransmitters. Its oxidation leads to electrophilic quinone, which covalently modifies nucleophilic …