Massively parallel in vivo Perturb-seq screening
Advances in genomics have identified thousands of risk genes impacting human health and diseases, but the functions of these genes and their mechan…
Advances in genomics have identified thousands of risk genes impacting human health and diseases, but the functions of these genes and their mechan…
Astrocyte heterogeneity has been well explored, but our understanding of white matter (WM) astrocytes and their distinctions from gray matter (GM) …
Here we report a conserved transcriptomic signature of reduced fatty acid and lipid metabolism gene expression in a Drosophila model of C…
The phosphatase and tensin homolog (PTEN) is a vital protein that maintains an inhibitory brake for cellular proliferation and growth. Accordingly,…
Premature reproductive aging is linked to heightened stress sensitivity and psychological maladjustment across the life course. However, the brain …
The limited efficacy of antidepressants for major depressive disorder (MDD) underscores the urgent need to explore mechanisms behind treatment hete…
Alzheimer’s disease (AD) therapies utilizing amyloid-β (Aβ) immunization have shown potential in clinical trials. Yet, the mechanisms driving A…
Dopamine (DA) is one of the most important neurotransmitters. Its oxidation leads to electrophilic quinone, which covalently modifies nucleophilic …