Functional diversity of cardiac macrophages in health and disease
Macrophages make up a substantial portion of the stromal compartment of the heart in health and disease. In the past decade, the origins of these c…
Tag: Monocytes and macrophages
Metabolic Messengers: small extracellular vesicles
Small extracellular vesicles (sEVs) are signalling molecules and biomarkers of cell status that govern a complex intraorgan and interorgan communic…
Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation
Macrophages stimulated by lipopolysaccharide (LPS) generate mitochondria-derived reactive oxygen species (mtROS) that act as antimicrobial agents a…
Mechanical regulation of macrophage metabolism by allograft inflammatory factor 1 leads to adverse remodeling after cardiac injury
Myocardial infarction (MI) mobilizes macrophages, the central protagonists of tissue repair in the infarcted heart. Although necessary for repair, …
Macrophages: a double-edged sword in female reproduction and disorders
Reproduction consists of sequential inflammation-like events, primarily within the endometrium, from ovulation to embryo implantation, decidualizat…
Serotonin attenuates tumor necrosis factor-induced intestinal inflammation by interacting with human mucosal tissue
The intestine hosts the largest immune system and peripheral nervous system in the human body. The gut‒brain axis orchestrates communication betw…
Targeting of TAMs: can we be more clever than cancer cells?
With increasing incidence and geography, cancer is one of the leading causes of death, reduced quality of life and disability worldwide. Principal …
Targeting macrophage polarization by inhibiting Pim2 alleviates inflammatory arthritis via metabolic reprogramming
Macrophage polarization and energy metabolic reprogramming play pivotal roles in the onset and progression of inflammatory arthritis. Moreover, alt…