Imaging-guided precision hyperthermia with magnetic nanoparticles
Magnetic nanoparticles, including those formed of superparamagnetic iron oxides (SPIOs), are employed in various magnetic imaging and therapeutic t…
Tag: Nanoparticles
Multi-omics approaches to decipher the interactions of nanoparticles and biological systems
Understanding how engineered nanoparticles interact with biological systems is crucial for the development and implementation of nanoparticles in c…
Photothermal nanofiber-mediated photoporation for gentle and efficient intracellular delivery of macromolecules
Photoporation with free photothermal nanoparticles (NPs) is a promising technology for gentle delivery of functional biomacromolecules into living …
mRNA lipid nanoparticle formulation, characterization and evaluation
mRNA-based therapies have emerged as a cutting-edge approach for diverse therapeutic applications. However, substantial barriers exist that hinder …
Autophagosomes coated in situ with nanodots act as personalized cancer vaccines
Autophagosome cancer vaccines can promote cross-presentation of multiple tumour antigens and induce cross-reactive T cell responses. However, so fa…
AND-gated protease-activated nanosensors for programmable detection of anti-tumour immunity
The forward design of biosensors that implement Boolean logic to improve detection precision primarily relies on programming genetic components to …
Chemistry, manufacturing and controls strategies for using novel excipients in lipid nanoparticles
Lipid nanoparticles (LNPs) for nucleic acid delivery often use novel lipids as functional excipients to modulate the biodistribution, pharmacokinet…
Nature-inspired platform nanotechnology for RNA delivery to myeloid cells and their bone marrow progenitors
Nucleic acid therapeutics are used for silencing, expressing or editing genes in vivo. However, their systemic stability and targeted delivery to b…
Customizable virus-like particles deliver CRISPR–Cas9 ribonucleoprotein for effective ocular neovascular and Huntington’s disease gene therapy
In vivo CRISPR gene editing holds enormous potential for various diseases. Ideally, CRISPR delivery should be cell type-specific and time-restricte…