The changing treatment landscape of EGFR-mutant non-small-cell lung cancer
The discovery of the association between EGFR mutations and the efficacy of EGFR tyrosine-kinase inhibitors (TKIs) has revolutionized the tr…
Tag: Non-small-cell lung cancer
Immunotherapy for advanced-stage squamous cell lung cancer: the state of the art and outstanding questions
Immune-checkpoint inhibitors (ICIs) have transformed the treatment paradigm for advanced-stage squamous non-small-cell lung cancer (LUSC), a histol…
Circulating tumour DNA in early stage and locally advanced NSCLC: ready for clinical implementation?
Circulating tumour DNA (ctDNA) can be released by cancer cells into biological fluids through apoptosis, necrosis or active release. In patients wi…
Hiding in plain sight: NUT carcinoma is an unrecognized subtype of squamous cell carcinoma of the lungs and head and neck
In the past two decades, treatment for non-small-cell lung cancers (NSCLCs) and head and neck squamous cell carcinoma (HNSCC) has advanced consider…
Translating premalignant biology to accelerate non-small-cell lung cancer interception
Over the past decade, substantial progress has been made in the development of targeted and immune-based therapies for patients with advanced non-s…
Proteogenomic characterization reveals tumorigenesis and progression of lung cancer manifested as subsolid nodules
Lung adenocarcinoma (LUAD) radiologically displayed as subsolid nodules (SSNs) is prevalent. Nevertheless, the precise clinical management of SSNs …