Engineering circular RNA medicines
Circular RNAs (circRNAs) are a group of RNA molecules prevalent across various organisms and tissues and characterized by a covalent loop structure…
Tag: Nucleic-acid therapeutics
High-density brush-shaped polymer lipids reduce anti-PEG antibody binding for repeated administration of mRNA therapeutics
Messenger RNA lipid-nanoparticle-based therapies represent an emerging class of medicines for a variety of applications. However, anti-poly(ethylen…
Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids
The value of lipid nanoparticles (LNPs) for delivery of messenger RNA (mRNA) was demonstrated by the coronavirus disease 2019 (COVID-19) mRNA vacci…
Small circular RNAs as vaccines for cancer immunotherapy
Messenger RNA vaccines have shown strong prophylactic efficacy against viral infections. Here we show that antigen-encoding small circular RNAs (ci…
A capless hairpin-protected mRNA vaccine encoding the full-length Influenza A hemagglutinin protects mice against a lethal Influenza A infection
The success of mRNA vaccines in controlling the COVID 19 pandemic has confirmed the efficacy of synthetically synthesized mRNA in humans and has al…