Closing the loop with reactions at the N-terminus
Tag: Peptides
ADSL promotes autophagy and tumor growth through fumarate-mediated Beclin1 dimethylation
As an enzyme with a critical role in de novo purine synthesis, adenylosuccinate lyase (ADSL) expression is upregulated in various malignancies. How…
Deciphering molecular specificity in MCL-1/BAK interaction and its implications for designing potent MCL-1 inhibitors
The intricate interplay among BCL-2 family proteins governs mitochondrial apoptosis, with the anti-apoptotic protein MCL-1 primarily exerting its f…