Epigenetic editing of PCSK9 for a durable reduction in cholesterol
Tag: Pharmacology
Efficient and modular synthesis of ibogaine and related alkaloids
Anecdotal reports and preliminary clinical trials suggest that the psychoactive alkaloid ibogaine and its active metabolite noribogaine have powerf…
Pharmacodynamics of Akt drugs revealed by a kinase-modulated bioluminescent indicator
Measuring pharmacodynamics (PD)—the biochemical effects of drug dosing—and correlating them with therapeutic efficacy in animal models is cruci…
Molecular basis of β-arrestin coupling to the metabotropic glutamate receptor mGlu3
β-Arrestins (βarrs) mediate the desensitization and internalization of activated G-protein-coupled receptors (GPCRs). The molecular mechanism by …
DMR040, a potential antifungal compound
Based on DMR022 [(AEEA-Gly)2-AEEA-amphotericin B methyl ester, AEEA is the abbreviation of 8-amino-3,6-dioxaoctanoic acid] and DMR031 [(…
Sympathetic hypoactivity leads to hypocontractility of the corpus cavernosum in sickle cell mice: a mechanism contributing to priapism
Priapism, a prevalent complication in sickle cell disease (SCD) patients, manifests as prolonged and painful erections unrelated to sexual arousal.…