Drimane sesquiterpene esters produced by Aspergillus insuetus BF-1613 as inhibitors of sterol O-acyltransferase
A new drimane sesquiterpene ester, designated insuetusolate (1), and four reported ones (2–5) were isolated from a culture broth of…
Tag: Phenotypic screening
Discovery of new AMR drugs targeting modulators of antimicrobial activity using in vivo silkworm screening systems
Global concerns about drug-resistant bacteria have underscored the need for new antimicrobial drugs. Emerging strategies in drug discovery include …
Evaluation of tirandamycins with selective activity against Enterococci in the silkworm infection model
In the course of screening for anti-enterococcal antibiotics from microbial resources, a new tirandamycin congener (1), together with four k…