Mitigating the environmental effects of healthcare: the role of the endocrinologist
Human health depends on planetary health, and yet healthcare provision can have unintended consequences for the health of the planet. Emissions fro…
Tag: Physiology
Brain O-GlcNAcylation: Bridging physiological functions, disease mechanisms, and therapeutic applications
O-GlcNAcylation, a dynamic post-translational modification occurring on serine or threonine residues of numerous proteins, plays a pivotal role in …
It’s the little things. A framework and guidance for programs to care for infants 22–23 weeks’ gestational age
Neonatal intensive care units (NICUs) developing a tiny baby program—a clinical approach for care of infants born before 24 weeks’ gestation—…
Community composition and physiological plasticity control microbial carbon storage across natural and experimental soil fertility gradients
Many microorganisms synthesise carbon (C)-rich compounds under resource deprivation. Such compounds likely serve as intracellular C-storage pools t…
Rare variants in the melanocortin 4 receptor gene (MC4R) are associated with abdominal fat and insulin resistance in youth with obesity
Rare variants in melanocortin 4 receptor gene (MC4R) result in a severe form of early-onset obesity; however, it is unclear how these varian…
Intramyocellular lipid use is altered with exercise in males with childhood-onset obesity despite no differences in substrate oxidation
Compared to adulthood-onset obesity (AO), those with childhood-onset obesity (CO) are at greater risk of metabolic disease. However, the difference…
Western diet since adolescence impairs brain functional hyperemia at adulthood in mice: rescue by a balanced ω-3:ω-6 polyunsaturated fatty acids ratio
Obesity is a devastating worldwide metabolic disease, with the highest prevalence in children and adolescents. Obesity impacts neuronal function bu…