Tag: Population genetics
Comparative analysis of the Mexico City Prospective Study and the UK Biobank identifies ancestry-specific effects on clonal hematopoiesis
The impact of genetic ancestry on the development of clonal hematopoiesis (CH) remains largely unexplored. Here, we compared CH in 136,401 particip…
Evaluation of polygenic scores for hypertrophic cardiomyopathy in the general population and across clinical settings
Hypertrophic cardiomyopathy (HCM) is an important cause of morbidity and mortality, with pathogenic variants found in about a third of cases. Large…
Genetic analysis of a Yayoi individual from the Doigahama site provides insights into the origins of immigrants to the Japanese Archipelago
Mainland Japanese have been recognized as having dual ancestry, originating from indigenous Jomon people and immigrants from continental East Euras…
Mutualism reduces the severity of gene disruptions in predictable ways across microbial communities
Predicting evolution in microbial communities is critical for problems from human health to global nutrient cycling. Understanding how species inte…
Temporal stability of sex ratio distorter prevalence in natural populations of the isopod Armadillidium vulgare
In the terrestrial isopod Armadillidium vulgare, many females produce progenies with female-biased sex ratios due to two feminizing sex rati…
Transitions in sex determination mechanisms through parental and sexual antagonism
Sex chromosomes carry the sex-determining locus, causing them to be differently transmitted to and from females and males. These differences lead t…
A decision-making framework to maximise the evolutionary potential of populations – Genetic and genomic insights from the common midwife toad (Alytes obstetricans) at its range limits
Anthropogenic habitat modification and climate change are fundamental drivers of biodiversity declines, reducing the evolutionary potential of spec…
Too big to purge: persistence of deleterious Mutations in Island populations of the European Barn Owl (Tyto alba)
A key aspect of assessing the risk of extinction/extirpation for a particular wild species or population is the status of inbreeding, but the origi…