Tag: Predictive markers
Proteogenomic characterization reveals tumorigenesis and progression of lung cancer manifested as subsolid nodules
Lung adenocarcinoma (LUAD) radiologically displayed as subsolid nodules (SSNs) is prevalent. Nevertheless, the precise clinical management of SSNs …
Immunogenomic determinants of exceptional response to immune checkpoint inhibition in renal cell carcinoma
Immune checkpoint inhibitors can lead to ‘exceptional’, durable responses in a subset of persons. However, the molecular basis of exceptional r…
Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial
While observational studies and small pilot trials suggest that vitamin D, omega-3 and exercise may slow biological aging, larger clinical trials t…
Maternal immune activation imprints translational dysregulation and differential MAP2 phosphorylation in descendant neural stem cells
Alterations induced by maternal immune activation (MIA) during gestation impact the subsequent neurodevelopment of progeny, a process that in human…
Using twin-pairs to assess potential bias in polygenic prediction of externalising behaviours across development
Prediction from polygenic scores may be confounded by sources of passive gene-environment correlation (rGE; e.g. population stratification, assorta…
A simple platelet biomarker is associated with symptom severity in major depressive disorder
Previous studies have shown that the heterotrimeric G protein, Gsalpha (Gsα), is ensconced predominantly in lipid rafts in acutely depressed subje…
Neuroinflammatory fluid biomarkers in patients with Alzheimer’s disease: a systematic literature review
Neuroinflammation is associated with both early and late stages of the pathophysiology of Alzheimer’s disease (AD). Fluid biomarkers are gaining …
Mendelian randomization analysis revealed a gut microbiota-eye axis in acute anterior uveitis
Observational studies suggest that gut microbiome (GM) may contribute to acute anterior uveitis (AAU) development, but causality remains unclear. T…