Detection of protein oligomers with nanopores
Powerful single-molecule approaches have been developed for the accurate measurement of protein oligomers, but they are often low throughput and li…
Tag: protein aggregation
Expanding the molecular grammar of polar residues and arginine in FUS phase separation
A molecular grammar governing low-complexity prion-like domain phase separation (PS) has identified tyrosine and arginine as primary drivers via ar…
Isoaspartate-containing galanin in rat hypothalamus
The isoaspartate residue is a spontaneous, time-dependent post-translational modification (PTM) of proteins and peptides, associated with in vivo p…
Cathepsin B prevents cell death by fragmentation and destruction of pathological amyloid fibrils
Amyloid fibrils cause organ and tissue dysfunction in numerous severe diseases. Despite the prevalence and severity of amyloidoses, there is still …
Exploring immunotherapeutic strategies for neurodegenerative diseases: a focus on Huntington’s disease and Prion diseases
Immunotherapy has emerged as a promising therapeutic approach for the treatment of neurodegenerative disorders, which are characterized by the prog…