Standardized workflow for multiplexed charge detection mass spectrometry on orbitrap analyzers
Individual ion mass spectrometry (I2MS) is the Orbitrap-based extension of the niche mass spectrometry technique known as charge detecti…
Tag: Proteomics
An accessible workflow for high-sensitivity proteomics using parallel accumulation–serial fragmentation (PASEF)
Deep and accurate proteome analysis is crucial for understanding cellular processes and disease mechanisms; however, it is challenging to implement…
Plasma proteome variation and its genetic determinants in children and adolescents
Our current understanding of the determinants of plasma proteome variation during pediatric development remains incomplete. Here, we show that gene…
Implications of frequent hitter E3 ligases in targeted protein degradation screens
Targeted protein degradation (TPD) offers a promising approach for chemical probe and drug discovery that uses small molecules or biologics to dire…
In situ lysosomal proteomics enabled by bioorthogonal photocatalytic proximity labelling
In situ deciphering of lysosome proteomes is crucial for understanding cellular processes and diseases, but is challenging due to its digestive, ac…
Large-scale proteomic analyses of incident Parkinson’s disease reveal new pathophysiological insights and potential biomarkers
The early pathophysiology of Parkinson’s disease (PD) is poorly understood. We analyzed 2,920 Olink-measured plasma proteins in 51,804 UK Biobank…
Coordinated proteome change precedes cell lysis and death in a mat-forming cyanobacterium
Cyanobacteria form dense multicellular communities that experience transient conditions in terms of access to light and oxygen. These systems are p…
Deep proteome profiling of metabolic dysfunction-associated steatotic liver disease
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects roughly 1 in 3 adults and is a leading cause of liver transplants and live…