Standardized workflow for multiplexed charge detection mass spectrometry on orbitrap analyzers
Individual ion mass spectrometry (I2MS) is the Orbitrap-based extension of the niche mass spectrometry technique known as charge detecti…
Individual ion mass spectrometry (I2MS) is the Orbitrap-based extension of the niche mass spectrometry technique known as charge detecti…
Deep and accurate proteome analysis is crucial for understanding cellular processes and disease mechanisms; however, it is challenging to implement…
Our current understanding of the determinants of plasma proteome variation during pediatric development remains incomplete. Here, we show that gene…
Targeted protein degradation (TPD) offers a promising approach for chemical probe and drug discovery that uses small molecules or biologics to dire…
In situ deciphering of lysosome proteomes is crucial for understanding cellular processes and diseases, but is challenging due to its digestive, ac…
The early pathophysiology of Parkinson’s disease (PD) is poorly understood. We analyzed 2,920 Olink-measured plasma proteins in 51,804 UK Biobank…
Cyanobacteria form dense multicellular communities that experience transient conditions in terms of access to light and oxygen. These systems are p…
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects roughly 1 in 3 adults and is a leading cause of liver transplants and live…