Tag: Screening
Implications of frequent hitter E3 ligases in targeted protein degradation screens
Targeted protein degradation (TPD) offers a promising approach for chemical probe and drug discovery that uses small molecules or biologics to dire…
Mechanistic insights and approaches for beta cell regeneration
Diabetes is characterized by variable loss of insulin-producing beta cells, and new regenerative approaches to increasing the functional beta cell …
Multiplexed activity metabolomics for isolation of filipin macrolides from a hypogean actinomycete
Chemical and biological stimulus screening in a hypogean actinomycete was used to elicit secondary metabolism. Optimal biosynthesis of bioactive n…