Regulation of cGAS–STING signalling and its diversity of cellular outcomes
The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signalling pathway, which recognizes both pathogen DNA and host-deriv…
Tag: Signal transduction
STIM1-mediated NFAT signaling synergizes with STAT1 to control T-bet expression and TH1 differentiation
Stromal interaction molecule 1 (STIM1) is critical for store-operated Ca2+ entry (SOCE) and T cell activation. T helper 1 (TH…
The HRAS-binding C2 domain of PLCη2 suppresses tumor‐like synoviocytes and experimental arthritis in rheumatoid arthritis
Fibroblast-like synoviocytes (FLSs), which are stromal cells that play key roles in rheumatoid arthritis (RA) pathophysiology, are characterized by…
MYO1F regulates T-cell activation and glycolytic metabolism by promoting the acetylation of GAPDH
Proper cellular metabolism in T cells is critical for a productive immune response. However, when dysregulated by intrinsic or extrinsic metabolic …
β-hydroxybutyrylation and O-GlcNAc modifications of STAT1 modulate antiviral defense in aging
Aging changes the protein activity status to affect the body’s functions. However, how aging regulates protein posttranslational modifications (P…