Detection of protein oligomers with nanopores
Powerful single-molecule approaches have been developed for the accurate measurement of protein oligomers, but they are often low throughput and li…
Powerful single-molecule approaches have been developed for the accurate measurement of protein oligomers, but they are often low throughput and li…
Protein sequencing and the identification of post-translational modifications are key to understanding cellular signalling pathways and metabolic p…
Sensitive, rapid and label-free biochemical sensors are needed for many applications. In this protocol, we describe biochemical detection using FLO…
Robust expression of guide RNA (gRNA) is essential for successful implementation of CRISPR–Cas9 genome-editing methods. The gRNA components, such…
An ideal tool for the study of cellular biology would enable the measure of molecular activity nondestructively within living cells. Single-molecul…
Understanding the diverse dynamic behaviors of individual RNA molecules in single cells requires visualizing them at high resolution in real time. …
Bisphosphonate-related osteonecrosis of jaw (BRONJ) is characterized by impaired osteogenic differentiation of orofacial bone marrow stromal cells …
Naturally evolved T-cell receptors (TCRs) exhibit remarkably high specificity in discriminating non-self antigens from self-antigens under dynamic …