FGF-based drug discovery: advances and challenges
The fibroblast growth factor (FGF) family comprises 15 paracrine-acting and 3 endocrine-acting polypeptides, which govern a multitude of processes …
Tag: Structural biology
Transforming an ATP-dependent enzyme into a dissipative, self-assembling system
Nucleoside triphosphate (NTP)-dependent protein assemblies such as microtubules and actin filaments have inspired the development of diverse chemic…
Implications of frequent hitter E3 ligases in targeted protein degradation screens
Targeted protein degradation (TPD) offers a promising approach for chemical probe and drug discovery that uses small molecules or biologics to dire…
Quinone extraction drives atmospheric carbon monoxide oxidation in bacteria
Diverse bacteria and archaea use atmospheric CO as an energy source for long-term survival. Bacteria use [MoCu]-CO dehydrogenases (Mo-CODH) to conv…
Molecular basis of β-arrestin coupling to the metabotropic glutamate receptor mGlu3
β-Arrestins (βarrs) mediate the desensitization and internalization of activated G-protein-coupled receptors (GPCRs). The molecular mechanism by …
T-cell receptor structures and predictive models reveal comparable alpha and beta chain structural diversity despite differing genetic complexity
T-cell receptor (TCR) structures are currently under-utilised in early-stage drug discovery and repertoire-scale informatics. Here, we leverage a l…