Integrating metabolism and evolution towards the realization of synthetic life
Tag: Synthetic biology
Redirecting immune signaling with cytokine adaptors
Cytokines are signaling molecules that coordinate complex immune processes and are frequently dysregulated in disease. While cytokine blockade has …
Synthetic biomolecular condensates enhance translation from a target mRNA in living cells
Biomolecular condensates composed of proteins and RNA are one approach by which cells regulate post-transcriptional gene expression. Their formatio…
A cell-free biosensor signal amplification circuit with polymerase strand recycling
Cell-free systems are powerful synthetic biology technologies that can recapitulate gene expression and sensing without the complications of living…
Orthogonalized human protease control of secreted signals
Synthetic circuits that regulate protein secretion in human cells could support cell-based therapies by enabling control over local environments. A…
PROTAR Vaccine 2.0 generates influenza vaccines by degrading multiple viral proteins
Manipulating viral protein stability using the cellular ubiquitin-proteasome system (UPS) represents a promising approach for developing live-atten…