Programming biological communication between distinct membraneless compartments
Distinct membraneless organelles within cells collaborate closely to organize crucial functions. However, biosynthetic communicating membraneless o…
Tag: Synthetic biology
SEED-Selection enables high-efficiency enrichment of primary T cells edited at multiple loci
Engineering T cell specificity and function at multiple loci can generate more effective cellular therapies, but current manufacturing methods prod…
Nitroglycerin-responsive gene switch for the on-demand production of therapeutic proteins
Gene therapies and cell therapies require precise, reversible and patient-friendly control over the production of therapeutic proteins. Here we pre…
Non-viral intron knock-ins for targeted gene integration into human T cells and for T-cell selection
Current methods for the precise integration of DNA sequences into the genome of human T cells predominantly target exonic regions, which limits the…