Multi-omics approaches to decipher the interactions of nanoparticles and biological systems
Understanding how engineered nanoparticles interact with biological systems is crucial for the development and implementation of nanoparticles in c…
Tag: Transcriptomics
Construction of RNA reference materials for improving the quantification of transcriptomic data
RNA reference materials and their corresponding reference datasets act as the ‘ground truth’ for the normalization of experimental values and a…
Linking single-cell transcriptomes with secretion using SEC-seq
Cells secrete numerous proteins and other biomolecules into their surroundings to achieve critical functions—from communicating with other cells …
PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors
Enlargement of the cerebrospinal fluid (CSF)-filled brain ventricles (ventriculomegaly) is a defining feature of congenital hydrocephalus (CH) and …
Genome-wide gene expression profiles throughout human malaria parasite liver stage development in humanized mice
Gene expression of Plasmodium falciparum (Pf) liver-stage (LS) parasites has remained poorly characterized, although they are major v…
Multiplexed spatial mapping of chromatin features, transcriptome and proteins in tissues
The phenotypic and functional states of cells are modulated by a complex interactive molecular hierarchy of multiple omics layers, involving the ge…
Scalable co-sequencing of RNA and DNA from individual nuclei
The ideal technology for directly investigating the relationship between genotype and phenotype would analyze both RNA and DNA genome-wide and with…
Cell2fate infers RNA velocity modules to improve cell fate prediction
RNA velocity exploits the temporal information contained in spliced and unspliced RNA counts to infer transcriptional dynamics. Existing velocity m…
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Microglia, the innate immune cells of the central nervous system, have been genetically implicated in multiple neurodegenerative diseases. Mapping …