The maternal-to-zygotic transition: reprogramming of the cytoplasm and nucleus
A fertilized egg is initially transcriptionally silent and relies on maternally provided factors to initiate development. For embryonic development…
Tag: Translation
Synthetic biomolecular condensates enhance translation from a target mRNA in living cells
Biomolecular condensates composed of proteins and RNA are one approach by which cells regulate post-transcriptional gene expression. Their formatio…
SNORD113–114 cluster maintains haematopoietic stem cell self-renewal via orchestrating the translation machinery
Haematopoietic stem cells (HSCs) self-renew and differentiate to replenish the pool of blood cells, which require a low but finely tuned protein sy…
An avoidance segment resolves a lethal nuclear–mitochondrial targeting conflict during ribosome assembly
The correct sorting of nascent ribosomal proteins from the cytoplasm to the nucleus or to mitochondria for ribosome production poses a logistical c…
Functional screen identifies RBM42 as a mediator of oncogenic mRNA translation specificity
Oncogenic protein dosage is tightly regulated to enable cancer formation but how this is regulated by translational control remains unknown. The My…
Internal cap-initiated translation for efficient protein production from circular mRNA
Circular mRNA faces challenges in enhancing its translation potential as an RNA therapeutic. Here we introduce two molecular designs that bolster c…
Critical and differential roles of eIF4A1 and eIF4A2 in B-cell development and function
Eukaryotic initiation factor 4 A (eIF4A) plays critical roles during translation initiation of cellular mRNAs by forming the cap-binding eIF4F co…