Neoadjuvant triplet immune checkpoint blockade in newly diagnosed glioblastoma
Glioblastoma (GBM) is an aggressive primary adult brain tumor that rapidly recurs after standard-of-care treatments, including surgery, chemotherap…
Tag: Tumour immunology
B cell immunometabolism in health and disease
B cells have crucial roles in the initiation and progression of many pathological conditions, and several therapeutic strategies have targeted the …
The rewired immune microenvironment in leukemia
Leukemias are a class of human cancers that originate from hematopoietic progenitors and are characterized by extensive remodeling of the immune mi…
ImmuneLENS characterizes systemic immune dysregulation in aging and cancer
Recognition and elimination of pathogens and cancer cells depend on the adaptive immune system. Thus, accurate quantification of immune subsets is …
Alterations in PD-L1 succinylation shape anti-tumor immune responses in melanoma
Tumors undergo metabolic reprogramming to meet the energetic, synthetic and redox demands essential for malignancy, often characterized by increase…
ADSL-generated fumarate binds and inhibits STING to promote tumour immune evasion
Highly aggressive tumours have evolved to restrain the cGAS–STING pathway for immune evasion, and the mechanisms underlying this hijacking remain…