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Reduction of deforestation by agroforestry in high carbon stock forests of Southeast Asia

Agroforestry is widely practised for local social-economic and ecological co-benefits, however whether it is beneficial at landscape scale in terms of decreasing deforestation rates remains unclear. Using causal inference, we found local variability but an overall net reduction in deforestation attributed to agroforestry of 250,319 ha yr−1 or 58.8 ± 15.5 Mt CO2 equivalent per year across 38 subnational regions in Southeast Asia (P < 0.05), including high carbon stock forests and deforestation hotspots. These findings provide support and nuance for agroforestry as a natural climate solution especially in biodiverse Southeast Asian forests, which harbour high levels of carbon stocks.

The role of rivers in the origin and future of Amazonian biodiversity

The rich biodiversity of Amazonia is shaped geographically and ecologically by its rivers and their cycles of seasonal flooding. Anthropogenic effects, such as deforestation, infrastructure development and extreme climatic events, threaten the ecological processes sustaining Amazonian ecosystems. In this Review, we explore the coupled evolution of Amazonian rivers and biodiversity associated with terrestrial and seasonally flooded environments, integrating geological, climatic, ecological and genetic evidence. Amazonia and its fluvial environments are highly heterogeneous, and the drainage system is historically dynamic and continually evolving; as a result, the discharge, sediment load and strength of rivers as barriers to biotic dispersal has changed through time. Ecological affinities of taxa, drainage rearrangements and variations in riverine landscape caused by past climate changes have mediated the evolution of the high diversity found in modern-day Amazonia. The connected history of the region’s biodiversity and landscape provides fundamental information for mitigating current and future impacts. However, incomplete knowledge about species taxonomy, distributions, habitat use, ecological interactions and occurrence patterns limits our understanding. Partnerships with Indigenous peoples and local communities, who have close ties to land and natural resources, are key to improving knowledge generation and dissemination, enabling better impact assessments, monitoring and management of the riverine systems at risk from evolving pressures.

Biodiversity offsets, their effectiveness and their role in a nature positive future

Biodiversity offsetting is a mechanism for addressing the impacts of development projects on biodiversity, but the practice remains controversial and its effectiveness generally poor. In the context of the Global Biodiversity Framework and the emergence of new approaches for mitigating damage, we need to learn from the past. In this Review, we explore biodiversity offsetting, its effectiveness and its future prospects, especially in relation to ‘nature positive’ goals. Offsets often fall short of their stated goal: to achieve at least no net loss of affected biodiversity. However, such failures are prominent because offsets have more explicit quantitative objectives than most other conservation approaches, whose effectiveness is also variable. These clear objectives provide the potential for the transparency that alternative approaches to addressing negative human impacts on biodiversity lack. Unfortunately, promising alternatives are scarce, so offsetting and offset-like mechanisms remain a necessary component of strategies to halt and reverse nature loss. However, improving their performance is essential. No quick and easy solution exists; instead, upholding best practice principles and rigorous implementation — including in the face of challenges from opposing narratives and interest groups — remains key.

Clinical practice recommendations for the diagnosis and management of X-linked hypophosphataemia

X-linked hypophosphataemia (XLH) is a rare metabolic bone disorder caused by pathogenic variants in the PHEX gene, which is predominantly expressed in osteoblasts, osteocytes and odontoblasts. XLH is characterized by increased synthesis of the bone-derived phosphaturic hormone fibroblast growth factor 23 (FGF23), which results in renal phosphate wasting with consecutive hypophosphataemia, rickets, osteomalacia, disproportionate short stature, oral manifestations, pseudofractures, craniosynostosis, enthesopathies and osteoarthritis. Patients with XLH should be provided with multidisciplinary care organized by a metabolic bone expert. Historically, these patients were treated with frequent doses of oral phosphate supplements and active vitamin D, which was of limited efficiency and associated with adverse effects. However, the management of XLH has evolved in the past few years owing to the availability of burosumab, a fully humanized monoclonal antibody that neutralizes circulating FGF23. Here, we provide updated clinical practice recommendations for the diagnosis and management of XLH to improve outcomes and quality of life in these patients.

Experts consensus on management of tooth luxation and avulsion

Traumatic dental injuries (TDIs) of teeth occur frequently in children and adolescents. TDIs that impact the periodontal tissues and alveolar tissue can be classified into concussion, subluxation, extrusive luxation, intrusive luxation, lateral luxation, and avulsion. In these TDIs, management of injured soft tissue, mainly periodontal ligament, and dental pulp, is crucial in maintaining the function and longevity of the injured teeth. Factors that need to be considered for management in laxation injuries include the maturation stage of the traumatic teeth, mobility, direction of displacement, distance of displacement, and whether there are alveolar fractures. In avulsion, the maturation stage of the permanent tooth, the out-socket time, storage media/condition of the avulsed tooth, and management of the PDL should also be considered. Especially, in this review, we have subdivided the immature tooth into the adolescent tooth (Nolla stage 9) and the very young tooth (Nolla stage 8 and below). This consensus paper aimed to discuss the impacts of those factors on the trauma management and prognosis of TDI to provide a streamlined guide for clinicians from clinical evaluation, diagnostic process, management plan decision, follow-up, and orthodontic treatment for tooth luxation and avulsion injuries.

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